Citation

Falkner AL, Wei D, Song A, Watsek LW, Chen I, Chen P, Feng JE, Lin D. Neuron 2020; ePub(ePub): ePub.

Affiliation

Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA; Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA.

Copyright

(Copyright © 2020, Cell Press)

DOI

10.1016/j.neuron.2020.02.014

PMID

32164875

Abstract

Although the ventromedial hypothalamus ventrolateral area (VMHvl) is now well established as a critical locus for the generation of conspecific aggression, its role is complex, with neurons responding during multiple phases of social interactions with both males and females. It has been previously unclear how the brain uses this complex multidimensional signal and coordinates a discrete action: the attack. Here, we find a hypothalamic-midbrain circuit that represents hierarchically organized social signals during aggression. Optogenetic-assisted circuit mapping reveals a preferential projection from VMHvl^vGlut2 to lPAG^vGlut2 cells, and inactivation of downstream lPAG^vGlut2 populations results in aggression-specific deficits. lPAG neurons are selective for attack action and exhibit short-latency, time-locked spiking relative to the activity of jaw muscles during biting. Last, we find that this projection conveys male-biased signals from the VMHvl to downstream lPAG^vGlut2 neurons that are sensitive to features of ongoing activity, suggesting that action selectivity is generated by a combination of pre- and postsynaptic mechanisms.

Copyright © 2020 Elsevier Inc. All rights reserved.

Language: en

Keywords

aggression; circuit; hypothalamus; jaw muscle; periaqueductal gray; social behavior