Citation

Goddard AW. Chronic Stress (Thousand Oaks) 2017; 1: e2470547017736038.

Copyright

(Copyright © 2017, SAGE Publications)

DOI

10.1177/2470547017736038

PMID

unavailable

Abstract

Panic disorder is an often chronic and impairing human anxiety syndrome, which frequently results in serious psychiatric and medical comorbidities. Although, to date, there have been many advances in the diagnosis and treatment of panic disorder, its pathophysiology still remains to be elucidated. In this review, recent evidence for a neurobiological basis of panic disorder is reviewed with particular attention to risk factors such as genetic vulnerability, chronic stress, and temperament. In addition, neuroimaging data are reviewed which provides support for the concept of panic disorder as a fear network disorder. The potential impact of the National Institute of Mental Health Research Domain Criteria constructs of acute and chronic threats responses and their implications for the neurobiology of panic disorder are also discussed.

Language: en

Keywords

panic disorder; brain imaging; genetics; acute fear; anxious temperament; chronic stress; functional neuroanatomy; pathophysiology; Research Domain Criteria