Citation

Saksvik SB, Karaliute M, Kallestad H, Follestad T, Asarnow RF, Vik A, Håberg AK, Skandsen T, Olsen A. J. Neurotrauma 2020; ePub(ePub): ePub.

Copyright

(Copyright © 2020, Mary Ann Liebert Publishers)

DOI

10.1089/neu.2019.6898

PMID

unavailable

Abstract

In this prospective longitudinal study, we aimed to determine the prevalence and stability of sleep-wake disturbance and fatigue in a large representative sample of patients (Trondheim mTBI follow-up study). We included 378 patients with mTBI (age 16-60), 82 matched trauma controls with orthopedic injuries, and 83 matched community controls. Increased sleep need, poor sleep quality, excessive daytime sleepiness and fatigue were assessed at two weeks, three months and 12 months after injury. Mixed logistic regression models were used to evaluate clinically relevant group differences longitudinally. The prevalence of increased sleep need, poor sleep quality and fatigue was significantly higher in patients with mTBI than in both trauma controls and community controls at all time points. More patients with mTBI reported problems with excessive daytime sleepiness compared to trauma controls, but not community controls, at all time points. Patients with complicated mTBI (intracranial findings on CT or MRI) had more fatigue problems compared to those with uncomplicated mTBI, at all three time points. In patients with mTBI who experienced sleep-wake disturbances and fatigue two weeks after injury, about half still had problems at three months and about one third at 12 months. Interestingly, we observed limited overlap between the different symptom measures; a large number of patients reported one specific problem with sleep-wake disturbance or fatigue rather than several problems. In conclusion, our results provide strong evidence that mTBI contributes significantly to the development and maintenance of sleep-wake disturbances and fatigue.

Language: en

Keywords

ADULT BRAIN INJURY; HUMAN STUDIES; TRAUMATIC BRAIN INJURY; CT SCANNING; MRI