Citation

Aghabozorg Afjeh SS, Shams J, Hamednia S, Boshehri B, Olfat A, Omrani MD. Pharmacogenomics 2020; ePub(ePub): ePub.

Copyright

(Copyright © 2020, Future Medicine)

DOI

10.2217/pgs-2020-0058

PMID

32893730

Abstract

High rates of mortality due to both suicide and medical comorbidities in bipolar patients can be decreased through the administration of lithium, which affects the cerebral endothelium as well as neurons. To investigate the role of ADCY2 in risk of bipolar disorder, we genotyped the ADCY2 rs2290910 in bipolar patients and healthy controls using amplification refractory mutation system PCR. This polymorphism was associated with risk of bipolar disorder (odds ratio [OR]: 0.430, 95% CI: 0.296-0.624; p = 0.001). The C allele was more frequent in suicide ideation group compared other groups (OR: 2.7, 95% CI: 1.386-5.302; p = 0.004). The T allele was more frequent in suicide attempt group compared with suicide ideation group (OR: 0.238, 95% CI: 0.111-0.509; p = 0.001).

Language: en

Keywords

bipolar disorder; suicidal behavior; rs2290910 variant