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Citation
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Hui L, Hu WM, Zhu ZH, Gao ST, Han M, Fan Y, Tian Q, Yin XY, Yuan Y, Jiang CX, Yin GZ, Jia QF, Zhang XY. Hum. Psychopharmacol. 2020; ePub(ePub): ePub. |
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Abstract
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BACKGROUND: Patients with schizophrenia are at a higher risk for suicide compared with the general population. Dopamine beta-hydroxylase (DβH) plays a key role in the conversion of dopamine to norepinephrine, which is related to suicidal behavior and cognitive regulation.
OBJECTIVE: To examine whether there is the effect of DβH 5'-insertion/deletion (Ins/Del) polymorphism on cognitive performance in suicide attempters with chronic schizophrenia.
METHODS: This polymorphism was detected in 114 suicide attempters and 617 non-suicide attempters with chronic schizophrenia. Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).
RESULTS: The allelic and genotypic frequencies of this polymorphism between two groups did not differ after controlling for covariates (both, p >.05). There were no differences in RBANS scores between two groups after adjusting for covariates (all, p >.05). However, based on the genotype grouping in suicide attempters and non-attempters, the attention score significantly differed after adjusting for covariates (both, p <.05). Further analysis indicated that this polymorphism was associated with attention score in suicide attempters (p <.05), but not in non-suicide attempters (p >.05).
CONCLUSIONS: DβH 5'-Ins/Del polymorphism was not a risk locus of suicide attempters, but it was implicated in attention regulation in suicide attempters with chronic schizophrenia.
Language: en |