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Citation
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Dragašević-Mišković NT, Bobić V, Kostić M, Stankovic I, Radovanović S, Dimitrijević K, Svetel M, Petrović I, Đurić-Jovičić M. Clin. Neurol. Neurosurg. 2020; ePub(ePub): ePub. |
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Abstract
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OBJECTIVE: The goal of this study was to analyze how depression associated with Parkinson's disease (PD) affected gait variability in these patients using a dual-task paradigm. Additionally, the dependency of the executive functions and the impact of depression on gait variability were analyzed.
PATIENTS AND METHODS: Three subject groups were included: patients with PD, but no depression (PD-NonDep; 14 patients), patients with both PD and depression (PD-Dep; 16 patients) and healthy controls (HC; 15 subjects). Gait was recorded using the wireless sensors. The participants walked under four conditions: single-task, motor dual- task, cognitive dual-task, and combined dual-task. Variability of stride length, stride duration, and swing time was calculated and analyzed using the statistical methods.
RESULTS: Variability of stride duration and stride length were not significantly different between PD-Dep and PD-NonDep patients. The linear mixed model showed that swing time variability was statistically significantly higher in PD-Dep patients compared to controls (p = 0.001). Hamilton Disease Rating Scale scores were significantly correlated with the swing time variability (p = 0.01). Variability of all three parameters of gait was significantly higher while performing combined or cognitive task and this effect was more pronounced in PD-Dep group of patients.
CONCLUSIONS: Depression in PD was associated with swing time variability, and this effect was more prominent while performing a dual-task.
SIGNIFICANCE: Diagnosing and treating depression might be important for gait improvement and fall reduction in PD patients.
Language: en |