Citation

Olsavsky AK, Stoddard J, Erhart A, Tribble R, Kim P. Soc. Cogn. Affect. Neurosci. 2021; ePub(ePub): ePub.

Copyright

(Copyright © 2021, Oxford University Press)

DOI

10.1093/scan/nsab005

PMID

unavailable

Abstract

Maternal childhood maltreatment experiences (CME) may influence responses to infants and affect child outcomes. We examined associations between CME and mothers' neural responses and functional connectivity to infant distress. We hypothesized that mothers with greater CME would exhibit higher amygdala reactivity and amygdala-supplementary motor area (SMA) functional connectivity to own infant's cries. Postpartum mothers (N=57) assessed for CME completed an fMRI task with cry and white-noise stimuli. Amygdala region-of-interest and psychophysiological interaction analyses were performed. Our models tested associations of CME with activation and connectivity during task-conditions (own/other; cry/noise). Exploratory analyses with parenting behaviors were performed. Mothers with higher CME exhibited higher amygdala activation to own baby's cries vs. other stimuli (F1,392=6.9, p<0.01, N=57) and higher differential connectivity to cry vs. noise between amygdala and SMA (F1,165 = 22.3, p<0.001). Exploratory analyses revealed positive associations between both amygdala activation and connectivity and maternal non-intrusiveness (ps<0.05). Increased amygdala activation to own infant's cry and higher amygdala-SMA functional connectivity suggest motor responses to baby's distress. These findings were associated with less intrusive maternal behaviors. Follow up studies might replicate these findings, add more granular parenting assessments, and explore how cue processing leads to motivated maternal approach in clinical populations.

Language: en

Keywords

maltreatment; neuroimaging; amygdala; infant mental health; mother-child relationships