Citation

Yoshii T. Int. J. Mol. Sci. 2021; 22(4): e1730.

Copyright

(Copyright © 2021, Molecular Diversity Preservation International)

DOI

10.3390/ijms22041730

PMID

unavailable

Abstract

Post-traumatic stress disorder (PTSD) has a high lifetime prevalence and is one of the more serious challenges in mental health care. Fear-conditioned learning involving the amygdala has been thought to be one of the main causative factors; however, recent studies have reported abnormalities in the thalamus of PTSD patients, which may explain the mechanism of interventions such as eye movement desensitization and reprocessing (EMDR). Therefore, I conducted a miniature literature review on the potential contribution of the thalamus to the pathogenesis of PTSD and the validation of therapeutic approaches. As a result, we noticed the importance of the retinotectal pathway (superior colliculus-pulvinar-amygdala connection) and discussed therapeutic indicators.

Language: en

Keywords

PTSD; EMDR; fMRI; morphology; thalamus