Citation

Drelich G, Lewandowska-Stanek H, Jagiełło-Wójtowicz E. Przegl. Lek. 2007; 64(4-5): 258-259.

Vernacular Title

Zachwianie rownowagi oksydoredukcyjnej w samobojczych zatruciach lekami

Affiliation

Regionalny Osrodek Toksykologii Klinicznej Samodzielny Publiczny Szpital Wojewodzki im. Jana Bozego w Lublinie. gdrelich@esculap.pl

Copyright

(Copyright © 2007, Przeglad Lekarski)

DOI

unavailable

PMID

17724881

Abstract

The aim of this study was to examine the association between suicidal poisoning with antidepressants and the oxidoreductive balance by evaluation of changes in activity of glutathione reductase (GR) and total antioxidative status (TAS) in serum. GR activity and TAS were determined in 29 patients hospitalized after suicidal poisoning with antidepressants and compared with the results of the control group consisting of 16 healthy people. For this purpose, RANDOX diagnostic sets were used. The GR activity and TAS were significantly lower in the examined group, compared with the control group. The results obtained show a significant reduction of GR activity and TAS level in patients with suicidal antidepressants poisoning. It seems, that the oxidoreductive balance is shift towards the oxidative potential and leads to the decrease of the organism's antioxidative potential, which is manifested by the increase of oxygen free radicals and the intensification of the oxidative stress.

Language: pl