Citation

Zhai XR, Zou ZS, Wang JB, Xiao XH. Front. Pharmacol. 2021; 12: e738577.

Copyright

(Copyright © 2021, Frontiers Media)

DOI

10.3389/fphar.2021.738577

PMID

34539416

Abstract

Herbal medicine is widely used in Asia as well as the west. Hepatotoxicity is one of the most severe side effects of herbal medicine which is an increasing concern around the world. Reynoutria multiflora (Thunb.) Moldenke (Polygonum multiflorum Thunb., PM) is the most common herb that can cause herb-induced liver injury (HILI). The recent scientific and technological advancements in clinical and basic research are paving the way for a better understanding of the molecular aspects of PM-related HILI (PM-HILI). This review provides an updated overview of the clinical characteristics, predisposing factors, hepatotoxic components, and molecular mechanisms of PM-HILI. It can also aid in a better understanding of HILI and help in further research on the same.

Language: en

Keywords

drug-induced liver injury; herb-induced liver injury; molecular mechanisms; Polygonum multiflorum Thunb.; predisposing factors; Reynoutria multiflora (Thunb.) Moldenke