Citation

Zhang L, Ren H, Zhang R, Chen M, Li R, Shi L, Yao D, Gao J, Hu Y. Cogn. Neurodyn. 2022; 16(5): 1003-1011.

Copyright

(Copyright © 2022, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s11571-021-09766-y

PMID

36237414

PMCID

PMC9508310

Abstract

Generally, the readiness potential (RP) is considered to be the scalp electroencephalography (EEG) activity preceding movement. In our previous study, we found early RP was absent among approximately half of the subjects during instructed action, but we did not identify the mechanism causing the disappearance of the RP. In this study, we investigated whether the time-estimation process could cause the disappearance of the RP. First, we designed experiments consisting of motor execution (ME), motor execution after time estimation (MEATE), and time estimation (TE) tasks, and we collected and preprocessed the EEG data of 16 subjects. Second, we compared the event related potential (ERP) waveform and scalp topography between ME and MEATE tasks. Then, to explore the influence of time-estimation, we analyzed the difference in ERP between MEATE and TE tasks. Finally, we used source imaging to probe the activation of brain regions during the three tasks, and we calculated the average activation amplitude of eight motor related brain regions. We found that the RP occurred in the ME task but not in the MEATE task. We also found that the waveform of the difference in ERP between the MEATE and TE tasks was similar to that of the ME task. The results of source imaging indicated that, compared to the ME task, the activation amplitude of the supplementary motor area (SMA) decreased significantly for the MEATE task. Our results suggested that the time estimation process could cause the disappearance of the RP. This phenomenon might be caused by the counteraction of neural electrical activity related to time estimation and motor preparation in the SMA.

Language: en

Keywords

EEG; Readiness potential; Source imaging; Supplementary motor area; Time estimation