Citation

Edwards EM, Stanley JA, Daugherty AM, Lynn J, Borich MR, Fritz NE. J. Neuroimaging. 2022; ePub(ePub): ePub.

Copyright

(Copyright © 2022, Wiley)

DOI

10.1111/jon.13064

PMID

36266780

Abstract

BACKGROUND AND PURPOSE: Myelin water fraction (MWF) deficits as measured by myelin water imaging (MWI) have been related to worse motor function in persons with multiple sclerosis (PwMS). However, it is unknown if measures from MWI metrics in motor areas relate to fall risk measures in PwMS. The objective of this study was to examine the relationship between MWI measures in motor areas to performance on clinical measures of fall risk and disability in PwMS.

METHODS: Sixteen individuals with relapsing-remitting MS participated (1 male, 15 female; age 47.1 years [12.3]; Expanded Disability Status Scale 4.0 [range 0-6.5]) and completed measures of walking and fall risk (Timed 25 Foot Walk [T25FW] and Timed Up and Go). MWF and the geometric mean of the intra-/extracellular water T(2) (geomT(2IEW) ) values reflecting myelin content and contribution of large-diameter axons/density, respectively, were assessed in three motor-related regions.

RESULTS: The geomT(2IEW) of the corticospinal tract (r = -.599; p = .018) and superior cerebellar peduncles (r = -.613; p = .015) demonstrated significant inverse relationships with T25FW, suggesting that decreased geomT(2IEW) was related to slower walking. Though not significant, MWF in the corticospinal tract and superior cerebellar peduncles also demonstrated fair relationships with the T25FW, suggesting that worse performance on the T25FW was associated with lower MWF values.

CONCLUSIONS: MWI of key motor regions was associated with walking performance in PwMS. Further MWI studies are needed to identify relationships between pathology and clinical function in PwMS to guide targeted rehabilitation therapies aimed at preventing falls.

Language: en

Keywords

falls; gait; multiple sclerosis; corticospinal tract; myelin water imaging; superior cerebellar peduncle