Citation

Ververi C, Vincenti M, Salomone A. Biomed. Chromatogr. 2022; ePub(ePub): ePub.

Copyright

(Copyright © 2022, John Wiley and Sons)

DOI

10.1002/bmc.5555

PMID

36417316

Abstract

PURPOSE of this review study is to sum up the main recent advances reported in the scientific literature about the detection of common drugs of abuse in biological samples upon their collection by Dried Blood Spot (DBS) devices. The most recent, innovative and fully validated methods for the qualitative and/or quantitative detection of common drugs of abuse are reported, including alprazolam, clonazepam, diazepam, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methyl- enedioxyethylamphetamine (MDEA), amphetamine, methamphetamine, cocaine, tetrahydrocannabinol (THC), 6-monoacetylmorphine, morphine, codeine, hydromorphone, hydrocodone, oxycodone, noroxycodone, tramadol, methadone, buprenorphine, fentanyl, ketamine and their respective metabolites and γ-hydroxybutyric acid (GHB). DBS proved to be extremely promising for routine analysis of forensic cases, although large-scale experiments on real samples need to be performed to confirm the emerging advantages of the technique and remove the potential limitations still affecting its widespread application.

Language: en

Keywords

DBS; drugs of abuse; green chemistry; HRMS; LC-MS/MS