Citation

Trevisan N, Cattarinussi G, Olivo D, Di Ciano A, Giudetti L, Pampallona A, Kubera KM, Hirjak D, Wolf RC, Sambataro F. Brain Sci. 2023; 13(3).

Copyright

(Copyright © 2023, Switzerland Molecular Diversity Preservation International (MDPI) AG)

DOI

10.3390/brainsci13030474

PMID

36979284

PMCID

PMC10045997

Abstract

Antisocial behavior involves actions that disregard the basic rights of others and may represent a threat to the social system. The neural processes associated with being subject to antisocial behavior, including social victimization, are still unknown. In this study, we used a social interaction task during functional magnetic resonance imaging to investigate the neural bases of social victimization. Brain activation and functional connectivity (FC) were estimated and correlated with the Big 5 Questionnaire, Temperament Evaluation in Memphis, Pisa and San Diego (TEMPS-M), and a Questionnaire of Daily Frustration scores. During social victimization, the right occipital and temporal cortex showed increased activation. The temporal cortex also had reduced FC with homotopic areas. Compared to the prosocial interaction, social victimization showed hyperactivation of the dorsomedial and lateral prefrontal cortex, putamen, and thalamus and increased FC of the medial-frontal-striatal-thalamic areas with the ventrolateral prefrontal cortex, insula, dorsal cingulate, and postcentral gyrus. Lastly, neuroticism, irritable temperament, and frustration scores were correlated with the magnitude of neural responses to social victimization. Our findings suggest that social victimization engages a set of regions associated with salience, emotional processing, and regulation, and these responses can be modulated by temperamental and personality traits.

Language: en

Keywords

antisocial behavior; social interaction; functional connectivity; temperament; brain activation; functional magnetic resonance imaging; self-centered behavior