Citation

Martínez-Villota VA, Terroba-Chambi C, Castillo-Torres SA, Rossi M, Merello M. Eur. J. Neurol. 2023; ePub(ePub): ePub.

Copyright

(Copyright © 2023, European Federation of Neurological Societies, Publisher John Wiley and Sons)

DOI

10.1111/ene.15864

PMID

37183570

Abstract

BACKGROUND: Clinical correlates of fear of falling (FoF) are scarcely studied in patients with Progressive Supranuclear Palsy (PSP) and Multiple System Atrophy (MSA).

OBJECTIVE: To evaluate the clinical correlates of FoF in PSP and MSA.

METHODS: A cross-sectional study with motor , cognitive and psychiatric assessment and longitudinal evaluation of falls and FoF at 6-month follow-up.

RESULTS: Twenty-one patients with PSP-P, 22 with MSA (13 MSA-P and 9 MSA-C) and 22 healthy controls were evaluated. 76.2% of patients with PSP and 86.4%of patients with MSA had FoF regardless of falls. Berg Balance Scale (p<0.001), Tinetti Mobility Test (p<0.01), Beck Anxiety Inventory (p=0.001) and Beck Depression Inventory-II (p=0.01) correlated with FoF in patients with PSP and MSA, whereas Timed up and Go test (p=0.01) and Starkstein's Apathy Scale only in MSA (p=0.04).

CONCLUSION: Mobility, balance and gait performance as well as anxiety and depression in PSP and MSA, and apathy in MSA were determinants of FoF. These findings underline the importance of a multidisciplinary approach to FoF in neurodegenerative atypical parkinsonism.

Language: en

Keywords

falls; Fear of falling; atypical parkinsonism; Multiple system atrophy; Progressive Supranuclear Palsy