Citation

Cascino G, Canna A, Russo AG, Monaco F, Monteleone AM, Ceres R, Carfagno M, Di Salle F, Monteleone P. Eur. J. Neurosci. 2023; ePub(ePub): ePub.

Copyright

(Copyright © 2023, Federation of European Neuroscience Societies, Publisher John Wiley and Sons)

DOI

10.1111/ejn.16076

PMID

37369968

Abstract

Childhood maltreatment (CM) is associated with distinct clinical and biological characteristics in people with eating disorders (EDs). The measurement of local gyrification index (lGI) may help to better characterize the impact of CM on cortical structure. Thus, the present study investigated the association of CM with lGI in women with EDs. Twenty-six women with anorexia nervosa (AN) and 24 with bulimia nervosa (BN) underwent a 3T MRI scan. All participants filled in the Childhood Trauma Questionnaire. All neuroimaging data were processed by FreeSurfer. LGI maps underwent a general linear model to evaluate differences between groups with or without CM. People with AN and BN were merged together. Based on the Childhood Trauma Questionnaire cutoff scores, 24 participants were identified as maltreated and 26 as non-maltreated. Maltreated people with EDs showed a significantly lower lGI in the left middle temporal gyrus compared with non-maltreated people, whereas no differences emerged in the right hemisphere between groups. The present study showed that in people with EDs, CM is associated with reduced cortical folding in the left middle temporal gyrus, an area that could be involved in ED psychopathology. This finding corroborates the hypothesis of a 'maltreated ecophenotype', which argues that CM may allow to biologically, other than clinically, distinguish individuals with the same psychiatric disorder.

Language: en

Keywords

childhood maltreatment; eating disorders; anorexia nervosa; bulimia nervosa; gyrification index; maltreated ecophenotype