Citation

Casati S, Binda M, Dongiovanni P, Meroni M, D'Amato A, Roda G, Orioli M, Fabbro MD, Tartaglia GM. Clin. Chem. Lab. Med. 2023; ePub(ePub): ePub.

Copyright

(Copyright © 2023, Walter de Gruyter)

DOI

10.1515/cclm-2023-0343

PMID

unavailable

Abstract

The use of alternative matrices in toxicological analyses has been on the rise in clinical and forensic settings. Oral fluid (OF), as non-invasive fluid, has attracted attention in the field of drug screening, both for therapeutic and forensic purposes, as well as for medical diagnosis, clinical management, on-site (real time) doping and for monitoring environmental exposure to toxic substances. A good correlation between OF and blood is now established for drug concentrations. Therefore, OF might be a potential substitute of blood, especially for long-term surveillance (e.g., therapeutic drugs) or to screen a large number of patients, as well as for the development of salivary point-of-care technologies. In this review, we aimed to summarize and critically evaluate the current literature that focused on the comparison of drugs detection in OF and blood specimens.

Language: en

Keywords

alternative matrix; blood; drugs of abuse; drugs testing; saliva