SAFETYLIT WEEKLY UPDATE

We compile citations and summaries of about 400 new articles every week.
Email Signup | RSS Feed

HELP: Tutorials | FAQ
CONTACT US: Contact info

Search Results

Journal Article

Citation

Terranova C, Tucci M, Sartore D, Cavarzeran F, Di Pietra L, Barzon L, Palù G, Ferrara SD. J. Forensic Sci. 2013; 58(5): 1227-1232.

Affiliation

Department of Molecular Medicine, Forensic Toxicology Unit - Legal Medicine Unit, University Hospital of Padova, Via Falloppio 50, 35121, Padova, Italy.

Copyright

(Copyright © 2013, American Society for Testing and Materials, Publisher John Wiley and Sons)

DOI

10.1111/1556-4029.12201

PMID

23822588

Abstract

The aim of this study was to analyze the connection between alcohol dependence and criminal behavior by an integrated genetic-environmental approach. The research, structured as a case-control study, examined 186 alcohol-dependent males; group 1 (N = 47 convicted subjects) was compared with group 2 (N = 139 no previous criminal records). Genetic results were innovative, highlighting differences in genotype distribution (p = 0.0067) in group 1 for single-nucleotide polymorphism rs 3780428, located in the intronic region of subunit 2 of the GABA B receptor gene (GABBR2). Some environmental factors (e.g., grade repetition) were associated with criminal behavior; others (e.g., attendance at Alcoholics Anonymous) were inversely related to convictions. The concomitant presence of the genetic and environmental factors found to be associated with the condition of alcohol-dependent inmate showed a 4-fold increase in the risk of antisocial behavior. The results need to be replicated on a larger population to develop new preventive and therapeutic proposals.


Language: en

NEW SEARCH


All SafetyLit records are available for automatic download to Zotero & Mendeley
Print