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Journal Article


Navarro-Mateu F, Escámez T, Quesada MP, Alcaráz MJ, Vilagut G, Salmerón D, Huerta JM, Chirlaque MD, Navarro C, Kessler RC, Alonso J, Martínez S. Psychiatry Res. 2019; ePub(ePub): ePub.


Instituto de Neurociencias UMH-CSIC. Alicante, Spain; CIBER in Mental Health (CIBERSAM). Madrid, Spain.


(Copyright © 2019, Elsevier Publishing)






Information of the modulation effect of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) on post-traumatic stress disorder (PTSD) after earthquakes is scarce and contradictory. A cross-sectional face-to-face interview survey of a representative sample of the adults was carried out after the Lorca (Spain) earthquakes (May 11, 2011). Socio-demographic variables, DSM-IV diagnostic assessment and earthquake-related stressors were obtained from the Composite International Diagnostic Interview (CIDI). The triallelic and biallelic classification of the 5-HTTLPR polymorphism were genotyped from buccal swabs. Multivariate logistic regression models were used to predict PTSD, including interaction terms to explore gene-environment (G x E) interactions. The vast majority (83%, n = 341) of the Lorca survey respondents (n = 412, 71% response rate) were genotyped. Both classifications of the 5-HTTLPR genotype were in Hardy-Weinberg equilibrium. Prior lifetime PTSD was the only variable that remained a significant predictor after adjustments. There were no significant main effects of earthquake related stressors or 5-HTTLPR. However, G x E interactions of 5-HTTLPR with high emotional impact and prior lifetime anxiety disorders were statistically significant. These results provide new evidence of the modulation effect of the 5-HTTLPR polymorphisms on PTSD risk. This information might characterize people at higher risk of developing PTSD after an earthquake exposure.

Copyright © 2019. Published by Elsevier B.V.

Language: en


5-HTTLPR polymorphisms; Gene-environment interaction; Post-traumatic stress disorder


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