Citation

Dillon KA, Gross-Isseroff R, Israeli M, Biegon A. Brain Res. 1991; 554(1-2): 56-64.

Affiliation

Department of Psychiatry, NYU Medical Center.

Copyright

(Copyright © 1991, International Brain Research Organization, Publisher Elsevier Publishing)

DOI

unavailable

PMID

1834306

Abstract

Quantitative autoradiographic analysis of serotonin 5-HT1A receptors in the human brain, using 3H.8-OH-DPAT as a ligand, reveals region-specific decreases in receptor labeling with age in several cortical and hippocampal regions and in the raphe nuclei. This is due to a change in receptor density (Bmax) with no apparent change in affinity (Kd) as affirmed by saturation binding analysis on representative cortical regions. The presence of alcohol is associated with decreased binding in several cortical gyri. Suicide, gender and postmortem delay had no effect on 8-OH-DPAT binding.

Language: en