Citation

Ellinwood EH, Linnoila M, Easler ME, Molter DW. Psychopharmacology 1983; 79(2-3): 137-141.

Copyright

(Copyright © 1983, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

6133300

Abstract

Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component that is followed by a much slower blood-drug rise time. These pronounced early peak effects were not shared by alcohol, and contribute significantly to the lack of correlation between impairment and DPL.

Language: en