Citation

Yuan TH, Kerns WP, Tomaszewski CA, Ford MD, Kline JA. J. Toxicol. Clin. Toxicol. 1999; 37(4): 463-474.

Affiliation

Carolinas Medical Center, Charlotte, North Carolina 28232, USA.

Copyright

(Copyright © 1999, Marcel Dekker)

DOI

unavailable

PMID

10465243

Abstract

CASE REPORT: This case series documents the clinical courses of 4 patients after verapamil overdose and 1 patient after amlodipine-atenolol overdose. All subjects had hypodynamic circulatory shock (hypotension, bradycardia, and acidosis) that was not adequately responsive to conventional treatment. After initiation of insulin-dextrose infusion, the hemodynamic status of all 5 patients stabilized and all patients survived. Plasma drug concentrations are reported for all cases and verapamil levels were extremely high in 2 patients (3710 ng/mL and 3980 ng/mL). However, because patients were not treated according to a standard protocol, each patient received variable other supportive measures and inotropic agents, and the infusion rates of insulin were variable among patients. This report provides preliminary evidence toward a larger trial of insulin-dextrose to treat hypodynamic shock from calcium channel blocker overdose.

Language: en