Citation

Wright RO, Perry HE, Woolf AD, Shannon MW. J. Toxicol. Clin. Toxicol. 1996; 34(6): 731-734.

Affiliation

Harvard University Medical School, Department of Medicine, Boston, Massachusetts, USA.

Copyright

(Copyright © 1996, Marcel Dekker)

DOI

unavailable

PMID

8941205

Abstract

CASE REPORT: A sixteen year-old-male with a history of glucose-6-phosphate dehydrogenase deficiency ingested an unknown amount of acetaminophen and presented to an emergency department 7.5 h later. He was afebrile. His serum acetaminophen level was 184 micrograms/mL, and his urine toxicologic screen was otherwise negative. Vomiting led to enrollment in a experimental protocol of intravenous N-acetylcysteine. He developed no evidence of subsequent chemical hepatitis but did develop a significant Coomb's negative hemolytic anemia. Hemoglobin on presentation was 14 g/dL and reached a nadir of 9.4 g/dL on admission day 4. CONCLUSION: Patients with glucose-6-phosphate dehydrogenase deficiency who overdose with acetaminophen should be monitored for the possible development of subsequent drug-induced hemolysis.

Language: en