Citation

Roth BA, Vinson DR, Kim S. J. Toxicol. Clin. Toxicol. 1998; 36(6): 609-612.

Affiliation

California Poison Control System-San Francisco Division, San Francisco General Hospital 94110, USA.

Copyright

(Copyright © 1998, Marcel Dekker)

DOI

unavailable

PMID

9776967

Abstract

CASE REPORT: A 39-year-old man ingested 35 g carisoprodol. He developed agitation, tachycardia, myoclonus, and coma. The blood carisoprodol was 71 micrograms/mL; the meprobamate was 26 micrograms/mL. DISCUSSION: Carisoprodol overdose is thought to induce simple central nervous system depression. This case demonstrates a severe overdose with symptoms more consistent with myoclonic encephalopathy. A review of cases presenting to the San Francisco Division of the California Poison Control System during 1997 suggests that carisoprodol is more commonly associated with agitation and bizarre movement disorders than the current literature suggests. The pharmacology and potential mechanisms of toxicity are discussed. CONCLUSION: Agitation, hypertonia, and a myoclonic encephalopathy may be seen with significant carisoprodol intoxication.

Language: en