Citation

Dunn RJ. J. Toxicol. Clin. Toxicol. 1998; 36(3): 239-242.

Affiliation

University of Sydney, Department of Emergency Medicine, Canberra Hospital, Garran, ACT, Australia. RobvDunn@msn.com

Copyright

(Copyright © 1998, Marcel Dekker)

DOI

unavailable

PMID

9656981

Abstract

Case reports: Reports of acute toxicity following sulfasalazine ingestion are rare. A case of an acute ingestion of sulfasalazine 50 g and paracetamol 50 g resulting in severe lactic acidosis, seizures, coagulopathy, hyperglycemia, ketosis, and methemoglobinemia is reported. Despite the ingestion of a large amount of paracetamol with serum paracetamol 5486 nmol/L (844 mg/L), significant hepatotoxicity did not occur. The patient recovered fully following administration of intravenous N-acetylcysteine, methylene blue, sodium bicarbonate, and supportive therapy.

Language: en