Citation

Torrente D, Cabezas R, Avila MF, Garcia-Segura LM, Barreto GE, Guedes RC. Neurosci. Lett. 2014; 565: 2-6.

Affiliation

Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife-PE, Brazil. Electronic address: guedes.rca@gmail.com.

Copyright

(Copyright © 2014, Elsevier Publishing)

DOI

10.1016/j.neulet.2013.12.058

PMID

24394907

Abstract

Cortical spreading depression (CSD) is a presumably pathophysiological phenomenon that interrupts local cortical function for periods of minutes to hours. This phenomenon is important due to its association with different neurological disorders such as migraine, malignant stroke and traumatic brain injury (TBI). Glial cells, especially astrocytes, play an important role in the regulation of CSD and in the protection of neurons under brain trauma. The correlation of TBI with CSD and the astrocytic function under these conditions remain unclear. This review discusses the possible link of TBI and CSD and its implication for neuronal survival. Additionally, we highlight the importance of astrocytic function for brain protection, and suggest possible therapeutic strategies targeting astrocytes to improve the outcome following TBI-associated CSD.

Language: en