Citation

Oshnokhah M, Bagheri M, Ghaneialvar H, Haghani K, Khorshidi A, Shahbazi A, Salari S. Basic Clin. Neurosci. 2021; 12(5): 667-674.

Copyright

(Copyright © 2021, Iran University of Medical Sciences in cooperation with the Iran Neuroscience Society and the Negah Institute for Scientific Communication)

DOI

10.32598/bcn.2021.1917.1

PMID

35173920

PMCID

PMC8818118

Abstract

INTRODUCTION: Oxidative stress plays a critical role in the pathogenesis of neurodegenerative and neuropsychiatric disorders. However, its role in suicidal behavior has not been clarified yet. Consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicide attempters in Ilam city.

METHODS: Fifty suicide attempters and 40 control subjects (volunteers) aged 18-35 years were studied in the current experiment. To consider the oxidant-antioxidant status, serum levels of Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide Dismutase (SOD), and the Total Antioxidant Capacity (TAC) were measured.

RESULTS: Serum levels of SOD and TAC were significantly lower in the suicide attempters group compared to the controls. Furthermore, serum NO level was significantly higher in the suicide attempters compared to the control groups. Interestingly, the serum level of MDA was significantly lower in the suicide attempters compared to the control groups.

CONCLUSION: The oxidative stress without MDA elevation, detected in suicide attempters, can be considered a biochemical hallmark in suicide behavior.

Language: en

Keywords

MDA; Oxidative stress; SOD; Suicide behavior; TAC