Citation

Pease M, Gonzalez-Martinez J, Puccio A, Nwachuku E, Castellano JF, Okonkwo DO, Elmer J. Ann. Neurol. 2022; ePub(ePub): ePub.

Copyright

(Copyright © 2022, John Wiley and Sons)

DOI

10.1002/ana.26443

PMID

35713346

Abstract

We determined incidence of post-traumatic epilepsy (PTE) after severe traumatic brain injury (TBI). Of 392 patients surviving to discharge, cumulative incidence of PTE was 25% at five years and 32% at fifteen years, an increase compared to historical reports. Among patients with one late seizure (>7 days post-trauma), risk of seizure recurrence was 62% after one year and 82% at ten years. Competing hazards regression identified age, decompressive hemicraniectomy, and intracranial infection as independent predictors of PTE. Patients with severe TBI and a single late post-traumatic seizure will likely require long-term antiseizure medicines. This article is protected by copyright. All rights reserved.

Language: en