Citation

Ciechanowski K, Borowiak KS, Potocka BA, Nowacka M, Dutkiewicz G. J. Toxicol. Clin. Toxicol. 1999; 37(7): 869-871.

Copyright

(Copyright © 1999, Marcel Dekker)

DOI

10.1081/clt-100102468

PMID

10630272

Abstract

In the past 5 years at our institution, 12 cases involving the ingestion of chlorpropamide 3-15 g were fatal. We report a 23-year-old woman with an estimated ingestion of chlorpropamide 5-10 g. Initial cardiovascular collapse, attributed to the blockade of potassium channel transport, responded to intensive support including 3 days of cardiac pacing. Urinary excretion of chlorpropamide and hypoglycemia persisted until day 27. The toxic mechanisms and high risk of chlorpropamide are summarized. A fatal therapeutic dose ratio as low as 4:1 has made this antidiabetic agent obsolete.

Language: en

Keywords

Adult; Chlorpropamide/*poisoning/urine; Electrocardiography; Female; Humans; Hypoglycemia/blood/*chemically induced; Hypoglycemic Agents/*poisoning/urine; Respiration, Artificial; Shock/chemically induced/physiopathology; Suicide, Attempted