Citation

Bédry R, Deschamps L, Pehourcq F, Moore N, Pillet O, Favarel-Garrigues JC. Vet. Hum. Toxico. 1999; 41(1): 20-22.

Copyright

(Copyright © 1999, American College of Veterinary Toxicologists)

DOI

unavailable

PMID

unavailable

Abstract

A 29-year-old male attempted suicide with 3000 mg clozapine, 150 mg zopiclone, alprazolam and unknown quantities of alcohol. He was admitted in a deep hypotonic coma with respiratory depression, inhalation pneumonia and vascular collapse. Symptomatic treatment involved mechanical ventilation, vascular filling and antibiotics. The patients was discharged from the Intensive Care Unit 72 h after the suicide attempt with no sequelae. To detect and quantify clozapine in plasma, high-pressure liquid chromatography showed a 4 h absorption phase and a peak serum concentration of 5200 ng/ml. Three successive elimination t(1/2) values of 38, 24 and 13 h were calculated.

Language: en

Keywords

adult; alcohol; alprazolam; article; artificial ventilation; case report; clozapine; coma; dose response; drug blood level; drug elimination; drug intoxication; human; intensive care unit; male; respiration depression; suicide attempt; toxicokinetics; zopiclone