Citation

Sokero TP, Melartin TK, Rytsälä HJ, Leskela US, Lestela-Mielonen PS, Isometsa ET. Br. J. Psychiatry 2005; 186: 314-318.

Affiliation

Head of Mood Disorders Research, Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. erkki.isometsa@ktl.fi.

Copyright

(Copyright © 2005, Royal College of Psychiatry)

DOI

10.1192/bjp.186.4.314

PMID

15802688

Abstract

BACKGROUND: There are few prospective studies on risk factors for attempted suicide among psychiatric out- and in-patients with major depressive disorder. AIMS: To investigate risk factors for attempted suicide among psychiatric out- and in-patients with major depressive disorder in the city of Vantaa, Finland. METHOD: The Vantaa Depression Study included 269 patients with DSM-IVmajor depressive disorder diagnosed using semistructured interviews and followed up at 6- and 18-month interviews with a life chart. RESULTS: During the 18-month followup, 8% of the patients attempted suicide. The relative risk of an attempt was The relative risk of an attempt was 2.50 during partial remission and 7.54 during a major depressive episode, compared with full remission (P 0.001). Numerous factors were associated with this risk, but lacking a partner, previous suicide attempts and total time spent in major depressive episodes were the most robust predictors. CONCLUSIONS: Suicide attempts among patients with major depressive disorder are strongly associated with the presence and severity of depressive symptoms and predicted by lack of partner, previous suicide attempts and time spent in depression. Reducing the time spent depressed is a credible preventive measure.