Citation

Zalsman G, Frisch A, Baruch-Movshovits R, Sher L, Michaelovsky E, King RA, Fischel T, Hermesh H, Goldberg P, Gorlyn M, Misgav S, Apter A, Tyano S, Weizman A. Int. J. Adolesc. Med. Health 2005; 17(3): 231-238.

Affiliation

Child and Adolescent Division, Geha Mental Health Center, Petach Tikva, and a Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. zalsman@neuron.cpmc.columbia.edu

Copyright

(Copyright © 2005, Freund Publishing)

DOI

unavailable

PMID

16231475

Abstract

Suicidal behavior runs in families and is partially genetically determined. Since greater serotonin 5-HT(2A) receptor binding has been reported in postmortem brain and platelets of suicide victims, the 5-HT(2A) receptor gene polymorphism T102C became one of the candidate sites in the study of suicide and impulsive-aggressive traits. However, studies that examined the association of this polymorphism with suicidality have contradictory results. This study used a family-based method and one homogenous ethnic group to overcome ethnic stratification in order to test this association. METHODS: Thirty families of inpatient adolescents from Jewish Ashkenazi origin, with a recent suicide attempt, were genotyped. All subjects were interviewed for clinical diagnosis, depressive and impulsive-aggressive traits and demographic data. Allele frequencies were assessed using the Haplotype Relative Risk method for trios. RESULTS: No difference was found in allelic distribution between transmitted and non-transmitted alleles. There was no significant association of genotype with any of the clinical traits CONCLUSIONS: These preliminary results suggest that the 5-HT(2A) T102C polymorphism is unlikely to be associated with suicidal behavior and related traits in adolescent suicide attempters.

Language: en