Citation

Pagonis TA, Angelopoulos NV, Koukoulis GN, Hadjichristodoulou CS, Toli PN. Eur. Psychiatry 2006; 21(8): 563-569.

Affiliation

Department of Psychiatry, Thessaly University Medical School, Panagouli 12, 41222 Larissa, Greece. tpsportmed@the.forthnet.gr

Copyright

(Copyright © 2006, Elsevier Publishing)

DOI

10.1016/j.eurpsy.2005.11.002

PMID

16529916

Abstract

INTRODUCTION: Anabolic androgenic steroids (AAS) are derived by chemical manipulation of the testosterone molecule. The specified category of drugs produces anabolic, androgenic and psycho-active effects including elevated aggressive, hostile, violent and anti social behavior. OBJECTIVE: The objective of this case report observational study was to evaluate the possible psychological consequences of AS use in the twin user of each pair, compared with the non-user twin. METHODOLOGY: We studied two pairs of male monozygotic twins: one pair 24 years old and the other 31 years old, with absolute genome and phenotype similarity. One of the twins of each pair used AAS while the other did not. Both pairs lived in Hellenic provincial towns and followed a common training and nutrition regime. The psychometric instruments used were the Symptoms Check List-90 (SCL-90) and the Hostility and Direction of Hostility Questionnaire (HDHQ). The psychometric evaluations took place within a time interval of 6 months. RESULTS: The study found high levels of aggressiveness, hostility, anxiety and paranoid ideation in the twins who used AS. The non-user twins showed no deviation from their initial status. CONCLUSION: The use of AAS induced several important psychiatric changes in monozygotic twins which were not present in the twin who did not use AAS.

Language: en