Citation

Strauss J, McGregor S, Freeman N, Tiwari AK, George CJ, Kovács M, Kennedy JL. Psychiatry Res. 2012; 197(1-2): 49-54.

Affiliation

Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.

Copyright

(Copyright © 2012, Elsevier Publishing)

DOI

10.1016/j.psychres.2011.11.022

PMID

22460132

Abstract

Childhood-onset mood disorders (COMD) are serious affective disorders with deleterious developmental sequelae including interpersonal dysfunction, psychotic symptoms and suicidal behavior. The current study examines 10 markers from two early-immediate genes for association with COMD and suicide attempt (SA) - HOMER1 and human neuronal pentraxin II (NPTX2). We examined individuals diagnosed with COMD versus matched controls, as well as individuals with COMD and a history of at least one lifetime SA versus COMD participants with no history of SA. No genotypic association was noted between any of the single nucleotide polymorphisms (SNPs) and COMD (all p-values>0.11). Our sample yielded a nominally significant allelic association between the HOMER1 rs7713917 SNP and COMD (p=0.04). We report genotype associations between HOMER1 rs2290639 and SA (p=0.003) and also between NPTX2 markers rs705315 (p=0.01) and rs1681248 (p=0.006) and SA, findings that remained statistically significant after multiple test correction. A three-way interaction was observed among HOMER1 rs4704560, rs2290639 and NPTX2 rs705318 (p=0.015). The associations we describe for HOMER1 and NPTX2 with SA should be considered preliminary until replicated.

Language: en