Citation

Heinzerling KG, Gadzhyan J, van Oudheusden H, Rodriguez F, McCracken J, Shoptaw S. J. Adolesc. Health 2013; 52(4): 502-505.

Affiliation

UCLA Center for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, California. Electronic address: KHeinzerling@mednet.ucla.edu.

Copyright

(Copyright © 2013, Elsevier Publishing)

DOI

10.1016/j.jadohealth.2012.10.275

PMID

23333007

Abstract

PURPOSE: To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents. METHODS: Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling. RESULTS: Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo (p = .043) and males (p = .005) respectively. CONCLUSIONS: Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.

Language: en