Citation

Sood S, Howell J, Sundararajan V, Angus P, Gow PJ. J. Gastroenterol. Hepatol. 2013; 28(8): 1356-1360.

Affiliation

Department of Gastroenterology, Austin Health, Heidelberg, Victoria, Australia.

Copyright

(Copyright © 2013, John Wiley and Sons)

DOI

10.1111/jgh.12196

PMID

23489151

Abstract

BACKGROUND AND AIM: Paracetamol is the most frequently used analgesic in Australia and can be purchased without a prescription. We aimed to investigate the epidemiology and outcome of paracetamol overdoses occurring in Victoria, Australia. METHODS: The Victorian admitted episode dataset was examined for all patients who had a diagnosis of paracetamol poisoning (ICD-10-AM: T39.1) or paracetamol adverse effect in therapeutic use (Y45.5) from 1(st) July 2000 - 30(th) June 2007. Data extracted included all ICD-10 codes related to their admissions, gender, age-range, date of admission and cause of death (if applicable). RESULTS: Over 7 years there was a total of 14,662 hospital admissions for paracetamol overdose with a mean of 2,095 cases per year. Accidental overdoses comprised 15% (n=2,149) of cases. The overdose rate fell from 46 cases per 100,000 in 2001 to 39 cases per 100,000 in 2006 (p<0.001). Most overdoses occurred in women (71%) and patients between 15 and 50 years old comprised 78% of all cases. Complications and mortality were relatively uncommon, with only 26 deaths directly attributable to paracetamol overdose over the 7 years. No child under 15 years old died from their overdose. CONCLUSION: Admission to Victorian hospitals with paracetamol overdose presents an enormous and in many cases preventable health care burden. Fortunately there has been a gradual fall in admissions and most cases appear relatively benign. Further reductions in overdose could be achieved with increased awareness by physicians and the general public regarding the potential for accidental overdose, and increasing funding for mental health initiatives.

Language: en